rs1624389

This variant is located in the ZDHHC5 gene.

▶

GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

glomerular filtration rate

Liu H et al. “Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.” Nature Genetics 54(7):950-962 (2022)

Allele G

OR 7.19

p 6.0e-13

N 1,508,659

Large GWAS

multi-ancestry

smoking cessation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele G

OR 0.01

p 5.0e-10

N 1,400,535

Large GWAS

European, East Asian, Hispanic or Latin American, African unspecified

About ZDHHC5

Enables protein-cysteine S-palmitoyltransferase activity. Involved in positive regulation of defense response; positive regulation of protein localization to plasma membrane; and protein localization to plasma membrane. Acts upstream of or within protein palmitoylation. Located in nucleoplasm; phagocytic vesicle; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all ZDHHC5 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Loading comments…