rs1627527

This is a upstream gene variant variant in the MFSD12 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

occupational attainment

Ko H et al. “Genome-wide association study of occupational attainment as a proxy for cognitive reserve.” Brain : a Journal of Neurology 145(4):1436-1448 (2022)

Allele A

OR 0.04

p 5.0e-8

N 248,847

Large GWAS

European

About MFSD12

Enables cysteine transmembrane transporter activity. Involved in cysteine transmembrane transport; pigment metabolic process involved in pigmentation; and regulation of melanin biosynthetic process. Located in lysosome and melanosome. Part of late endosome. [provided by Alliance of Genome Resources, Jul 2025]

View all MFSD12 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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