rs1629816

This is a upstream gene variant variant in the GHRL gene.

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Research that mentions this SNP (1)

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Polymorphism of regulatory region of GHRL gene (‐2531C>T) as a promising predictive factor for radiotherapy‐induced oral mucositis in patients with head neck cancer
AssociationN=65Anna Brzozowska et al.(2018)· Head & Neck

This case-control study examined the association between GHRL gene polymorphism (rs1629816, c.-2531C>T) and radiotherapy-induced oral mucositis in 65 head and neck cancer patients. The AA genotype showed a 7-fold decrease in risk for grades 2-3 oral mucositis in week 6 of radiotherapy (OR 0.14; 95% CI 0.02-0.98; P=0.0481), suggesting ghrelin's protective role in modulating inflammatory response to radiation.

Traits studied:head and neck canceroral mucositisradiotherapy-induced toxicity
PubMedDOIMetascience Observatory

About GHRL

This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression. [provided by RefSeq, Nov 2014]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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