rs1653625

This variant is located in the P2RX7 gene.

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Research that mentions this SNP (1)

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Analysis of a polymorphic microRNA target site in the purinergic receptor P2RX7 gene
ReviewOmar Abdul Rahman et al.(2010)· ELECTROPHORESIS

This narrative review examines the role of microRNAs (miRNAs) in neuropsychiatric disorders including schizophrenia, bipolar disorder, major depression, Alzheimer's disease, and Parkinson's disease. The paper synthesizes studies on miRNA expression alterations in peripheral tissues and genetic variants in miRNA-related genes (SNPs in miRNAs, miRNA target genes, and miRNA processing genes), highlighting the potential of miRNAs as biomarkers for diagnosis and prognosis of brain diseases.

Traits studied:Alzheimer's diseaseAnxiety disorderBipolar disorderFrontotemporal lobar degenerationMajor depressionMild cognitive impairmentObsessive-compulsive disorderPanic disorderParkinson's diseaseSchizophreniaTourette's syndrome
PubMedDOIMetascience Observatory

About P2RX7

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]

View all P2RX7 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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