rs16856785
This is a intron variant variant in the NOS1AP gene.
▶Research that mentions this SNP (1)
▶NOS1AP variant associated with incidence of type 2 diabetes in calcium channel blocker users in the Atherosclerosis Risk in Communities (ARIC) studyAssociationN=11,945Chu AY et al.(2010)· Diabetologia
In the ARIC study of 9,221 white and 2,724 African-American participants over 9 years of follow-up, rs10494366 in NOS1AP was validated as associated with reduced incidence of type 2 diabetes in calcium channel blocker (CCB) users (HR 0.57, 95% CI 0.35-0.92, p=0.016). The G allele was also associated with lower fasting glucose levels (p=0.037) in CCB users, and the association remained significant in time-dependent analysis (HR 0.70, 95% CI 0.49-0.99, p=0.036). No other NOS1AP variants showed significant associations after multiple testing correction.
About NOS1AP
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]
View all NOS1AP variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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