rs16861194

Case-control study of 518 type 2 diabetes cases and 518 controls in a Karnataka (Indian) population examined the association of three SNPs with T2D susceptibility and obesity. PPAR-γ2 rs1801282 and FTO rs9939609 were significantly associated with T2D in the overall sample (OR=1.42, P=0.02 and OR=1.19, P=0.01 respectively), with effects primarily observed in the obese diabetic subgroup. ADIPOQ rs16861194 showed no significant association (OR=1.08, P=0.39). A meta-analysis of 22 studies on PPAR-γ2 and FTO variants in Asian populations confirmed FTO's significant risk association with T2D.

A hospital-based case-control study in rural and urban India (1,204 cases; 1,212 controls) examined genetic and lifestyle risk factors for breast cancer. Four SNPs in FGFR2 (rs1219648, rs2420946, rs2981575, rs2981582) showed positive associations with breast cancer (ORs 1.32-1.47). Additional SNPs in obesity and metabolic genes (rs374748 in FBN2, rs2922763 in HNF4G, rs2116830 in KCNMA1, rs11121832 in MTHFR, rs16886165 in MAP3K1, rs11594610 in TCF7L2, rs2274459 in MLN) were associated with increased breast cancer risk. Waist-to-hip ratio ≥0.95 showed strong association (OR 3.78; 95% CI 2.92-4.89), and women living first 20 years in rural areas showed protective effect (OR 0.77).

This case-control study of 1,028 endometrial cancer cases and 1,932 controls from Shanghai evaluated 87 SNPs in five obesity-related genes (ADIPOQ, ADIPOR1, ADIPOR2, LEP, LEPR). Three ADIPOQ SNPs (rs3774262 OR=0.68, rs1063539 OR=0.66, rs12629945) and one LEP SNP (rs2071045 OR=0.70) were significantly associated with reduced endometrial cancer risk. The ADIPOQ variants were also associated with lower body weight, waist circumference, and BMI in controls, suggesting a potential mechanism through obesity.

Cross-sectional study of 991 Greek children examining interactions between ADIPOQ gene polymorphisms (rs1501299 and rs17300539) and dietary fiber intake on serum adiponectin levels. The rs1501299 GG vs GT+TT polymorphism showed significant interaction with fiber intake (P=0.028): GG homozygotes had significantly higher adiponectin levels compared to T allele carriers under low fiber intake conditions (5.1±2.7 vs 4.2±2.3 μg/mL, P=0.020).

This case-control association study examined 41 tag and candidate SNPs in the adiponectin (ADIPOQ) and its receptor genes (ADIPOR1, ADIPOR2) in relation to insulin sensitivity measured by euglycemic clamp in 584 white and 119 African American adolescents and their parents (n=703 total). One SNP in ADIPOQ (rs822393, p=0.0034) reached corrected significance threshold in whites and accounted for 1.9% of variance in insulin sensitivity; four additional ADIPOQ SNPs (rs4632532, rs266729, rs182052, rs7649121) showed suggestive associations (p<0.05). Two SNPs in ADIPOR1 showed suggestive associations in African Americans. The results suggest genetic variants in adiponectin pathway genes influence insulin sensitivity, with age potentially modifying the effect.