rs16870989

This variant is located in the KCNIP4 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

response to angiotensin-converting enzyme inhibitor

Ghouse J et al. “Polygenic risk score for ACE-inhibitor-associated cough based on the discovery of new genetic loci.” European Heart Journal 43(45):4707-4718 (2022)
Allele A
OR 1.12
p 2.0e-22
N 78,000
Large GWAS
European

About KCNIP4

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

View all KCNIP4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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