rs16902359

This is a upstream gene variant variant in the CASC11 gene.

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Research that mentions this SNP (1)

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Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry
AssociationN=1,163Prodipto Pal et al.(2009)· The Prostate

This case-control study of 596 prostate cancer cases and 567 controls tested 49 tagging SNPs in the 8q24 region for association with prostate cancer susceptibility and tumor aggressiveness in men of European ancestry. After multiple testing correction, four SNPs showed significant association with PC susceptibility (rs1016342, rs1378897, rs871135, rs6470517), while rs6470517 was significantly associated with aggressive tumor phenotypes (Gleason score and TNM staging, P = 10^-4 to 10^-5). Meta-analysis of rs1447295 showed a pooled odds ratio of 1.38 (95% CI: 1.30-1.46).

Traits studied:Prostate cancer aggressivenessProstate cancer susceptibilityTumor grade (Gleason score)Tumor stage (TNM staging)
PubMedDOIMetascience Observatory

About CASC11

Enables chromatin-protein adaptor activity and promoter-enhancer loop anchoring activity. Involved in chromatin looping and positive regulation of transcription by RNA polymerase II. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

View all CASC11 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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