rs16903574

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

childhood onset asthma

Pividori M et al. “Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.” The Lancet. Respiratory Medicine 7(6):509-522 (2019)

Allele G

OR 1.24

p 9.0e-16

N 327,670

Large GWAS

European

asthma

Han Y et al. “Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.” Nature Communications 11(1):1776 (2020)

Allele G

OR —

p 2.0e-15

N 536,345

Large GWAS

multi-ancestry

Olafsdottir TA et al. “Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis.” Nature Communications 11(1):393 (2020)

Allele G

OR 1.09

p 5.0e-13

N 771,388

Large GWAS

European

Zhu Z et al. “Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.” The European Respiratory Journal 54(6) (2019)

Allele G

OR 1.09

p 4.0e-12

N 394,283

Large GWAS

multi-ancestry

Ferreira MAR et al. “Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.” American Journal of Human Genetics 104(4):665-684 (2019)

Allele G

OR 1.10

p 9.0e-13

N 341,215

Large GWAS

European

Jia G et al. “Discerning asthma endotypes through comorbidity mapping.” Nature Communications 13(1):6712 (2022)

Allele G

OR 1.09

p 1.0e-9

N 305,098

Large GWAS

multi-ancestry

Johansson Å et al. “Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.” Human Molecular Genetics 28(23):4022-4041 (2019)

Allele G

OR —

p 8.0e-13

N 281,699

Major Consortium StudyLarge GWAS

European

allergic disease

Ferreira MA et al. “Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.” Nature Genetics 49(12):1752-1757 (2017)

Allele G

OR 1.07

p 1.0e-12

N 360,838

Large GWAS

European

eosinophil count

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)

Allele G

OR —

p 1.0e-11

N 583,850

Large GWAS

multi-ancestry

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)

Allele G

OR 0.03

p 1.0e-10

N 408,112

Large GWAS

European

asthma, chronic obstructive pulmonary disease

John C et al. “Genetic Associations and Architecture of Asthma-COPD Overlap.” Chest 161(5):1155-1166 (2022)

Allele G

OR 1.20

p 4.0e-10

N 48,428

Large GWAS

multi-ancestry

atopic eczema

Pasanen A et al. “Identifying Atopic Dermatitis Risk Loci in 1,094,060 Individuals with Subanalysis of Disease Severity and Onset.” The Journal of Investigative Dermatology 144(11):2417-2425 (2024)

Allele C

OR 0.08

p 1.0e-8

N 1,094,060

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs16903574

GWAS Catalog Trait Associations (6)

childhood onset asthma

asthma

allergic disease

eosinophil count

asthma, chronic obstructive pulmonary disease

atopic eczema

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