rs1690789

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

nodular goiter

White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)

Allele T

OR 0.10

p 8.0e-48

N 1,807,553

Large GWAS

European

thyroglobulin measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.07

p 3.0e-38

N 47,745

Large GWAS

European

thyroid carcinoma

White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)

Allele T

OR 0.16

p 1.0e-37

N 2,106,366

Large GWAS

European

emphysema pattern measurement

Castaldi PJ et al. “Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.” American Journal of Respiratory and Critical Care Medicine 190(4):399-409 (2014)

Allele C

OR 0.03

p 3.0e-8

N 9,614

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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