rs16945088

This longitudinal study examined 658 white participants from the Bogalusa Heart Study to investigate FTO gene effects on the onset age of overweight in adults. Using survival analysis on 30 FTO tag SNPs, rs9939609 showed the strongest association with overweight onset age (p=0.004), with genotype AA associated with significantly earlier onset (mean 22.82 years at 50% prevalence) compared to AT (28.96 years) and TT (27.76 years), with odds ratios of 0.52 (AA vs AT) and 0.58 (AA vs TT) for survival beyond age 18.

This longitudinal study examined FTO gene SNPs in 658 white subjects from childhood to adulthood. While FTO SNPs showed no significant association with birth weight or longitudinal BMI during childhood, three SNPs (rs9939609, rs17820875, and rs860713) were significantly associated with longitudinal BMI in adulthood (P = 5.3×10⁻⁵, 2.0×10⁻⁴, and 0.001, respectively). The study also identified interactions between birth weight and FTO variants, showing that lower birth weight predisposes to higher adult BMI depending on FTO risk genotypes.