rs16948230

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

post-traumatic stress disorder

Nievergelt CM et al. “Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.” Nature Genetics 56(5):792-808 (2024)
Allele A
OR 6.64
p 3.0e-11
N 1,280,933
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Genome‐wide association study of theta band event‐related oscillations identifies serotonin receptor geneHTR7influencing risk of alcohol dependence
AssociationN=2,159Mark Zlojutro et al.(2011)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This genome-wide association study identified four genes influencing theta band event-related oscillations, a heritable neuroelectrical trait associated with alcohol dependence. The strongest association for alcohol dependence risk was rs7916403 in serotonin receptor gene HTR7 on chromosome 10q23 (combined P = 1.53 × 10⁻⁴), with a recessive effect (OR = 1.32–1.37, P = 0.031–0.042). Other significant markers included rs4907240 in ARID5A (P = 3.68 × 10⁻⁶), rs13831 in GNAS1, and non-synonymous rs2294015 in ANXA13.

Traits studied:Alcohol dependenceTheta band event-related oscillations
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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