rs17034641

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

hematocrit

Hu Y et al. “Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.” American Journal of Human Genetics 108(5):874-893 (2021)

Allele A

OR 0.23

p 4.0e-17

N 62,487

Large GWAS

multi-ancestry

Kowalski MH et al. “Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations.” Plos Genetics 15(12):e1008500 (2019)

Allele A

OR —

β 0.080

p 9.0e-9

N 43,181

Major Consortium StudyLarge GWAS

multi-ancestry

Hodonsky CJ et al. “Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos.” Plos Genetics 13(4):e1006760 (2017)

Allele A

OR 0.36

p 3.0e-9

N 12,502

Large GWAS

Hispanic or Latin American

hemoglobin measurement

Hu Y et al. “Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.” American Journal of Human Genetics 108(5):874-893 (2021)

Allele A

OR 0.08

p 4.0e-16

N 62,461

Large GWAS

multi-ancestry

Hodonsky CJ et al. “Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos.” Plos Genetics 13(4):e1006760 (2017)

Allele A

OR 0.12

p 3.0e-8

N 12,502

Large GWAS

Hispanic or Latin American

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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