rs17052130
This is a intergenic variant variant in the SPRY3 gene.
▶GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Red cell distribution width
Hu Y et al. “Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.” American Journal of Human Genetics 108(5):874-893 (2021)
Allele C
OR 0.47
p 2.0e-62
N 28,982
Large GWAS
multi-ancestry
erythrocyte volume
Hu Y et al. “Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.” American Journal of Human Genetics 108(5):874-893 (2021)
Allele C
OR 1.39
p 2.0e-51
N 48,830
Large GWAS
multi-ancestry
erythrocyte count
Hu Y et al. “Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.” American Journal of Human Genetics 108(5):874-893 (2021)
Allele C
OR 0.10
p 6.0e-42
N 44,470
Large GWAS
multi-ancestry
mean corpuscular hemoglobin
Hu Y et al. “Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.” American Journal of Human Genetics 108(5):874-893 (2021)
Allele C
OR 0.41
p 5.0e-29
N 46,241
Large GWAS
multi-ancestry
pyruvate measurement
Nemkov T et al. “Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes.” Cell Metabolism 36(9):1979-1997.e13 (2024)
Allele C
OR 0.36
p 1.0e-28
N 11,334
Large GWAS
multi-ancestry
hemoglobin measurement
Hu Y et al. “Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.” American Journal of Human Genetics 108(5):874-893 (2021)
Allele C
OR 0.14
p 1.0e-15
N 62,461
Large GWAS
multi-ancestry
hematocrit
Hu Y et al. “Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.” American Journal of Human Genetics 108(5):874-893 (2021)
Allele C
OR 0.37
p 1.0e-12
N 62,487
Large GWAS
multi-ancestry
About SPRY3
Involved in negative regulation of MAPK cascade. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
View all SPRY3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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