rs17095355

This is a intergenic variant variant in the ADD3-AS1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

biliary atresia

Garcia-Barceló MM et al. “Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2.” Human Molecular Genetics 19(14):2917-25 (2010)
Allele T
OR 1.77
p 7.0e-9
N 762
Small GWAS
East Asian
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Research that mentions this SNP (1)

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Single nucleotide polymorphisms within Adducin 3 and Adducin 3 antisense RNA1 genes are associated with biliary atresia in Thai infants
AssociationN=222Wison Laochareonsuk et al.(2018)· Pediatric Surgery International

A Thai case-control study (56 BA cases, 166 controls) identified three SNPs in the ADD3 and ADD3-AS1 genes associated with biliary atresia (BA) susceptibility. Recessive variants in rs2501577 (ADD3, OR 1.81), rs11194981 (ADD3, OR 1.58), and rs17095355 (ADD3-AS1, OR 1.92) increased BA risk, with the T-G-C risk haplotype showing OR 2.23. SNP-SNP interaction analysis revealed a positive biological interaction between ADD3 and ADD3-AS1 variants (GG/TT combined genotype, OR 4.75).

Traits studied:Biliary atresia
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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