rs17116334
This is a upstream gene variant variant in the ZBTB16 gene.
▶Research that mentions this SNP (1)
▶Does parental expressed emotion moderate genetic effects in ADHD? an exploration using a genome wide association scanAssociationN=909Edmund J.S. Sonuga‐Barke et al.(2008)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
This genome-wide association study examined whether parental expressed emotion moderates genetic effects on ADHD symptoms and conduct disorder in 909 family trios (600,000 SNPs genotyped). No gene-by-environment interactions reached genome-wide significance. Nominal effects were observed with 36 uncorrected interaction P-values <10⁻⁵, implicating both novel genes and candidate genes. SNPs in SLC1A1 and NRG3 emerged as candidate genes for follow-up, though the authors emphasize these findings are preliminary and require replication.
About ZBTB16
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
View all ZBTB16 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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