rs1714984
This is a intron variant variant in the MYOCD gene.
▶Research that mentions this SNP (1)
▶Response to Methadone Maintenance Treatment is Associated with the MYOCD and GRM6 GenesAssociationN=116Francina Fonseca et al.(2010)· Molecular Diagnosis & Therapy
This case-control association study examined 116 opioid-dependent patients in methadone maintenance treatment (MMT) to identify genetic variants associated with treatment response. The study found significant epistatic interactions between rs1714984 (MYOCD) and rs953741 (GRM6), where carriers of the A allele at rs1714984 combined with the AG genotype at rs953741 showed increased risk of being nonresponders (OR=10.83, 95% CI 2.52-46.66, p=0.006). The study also identified rs1861591 (CRY1) as individually associated with nonresponder status (OR=2.99, p=0.035), though this did not survive multiple testing correction.
About MYOCD
This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
View all MYOCD variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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