rs17203398
This variant is located in the GALC gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
brain age measurement
Leonardsen EH et al. “Genetic architecture of brain age and its causal relations with brain and mental disorders.” Molecular Psychiatry 28(7):3111-3120 (2023)
Allele C
OR 0.16
p 1.0e-10
N 28,104
Large GWAS
About GALC
This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
View all GALC variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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