rs17216707
This is a regulatory region variant variant.
▶GWAS Catalog Trait Associations (11)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (11)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
calcium measurement
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele C
OR 0.06
p 4.0e-82
N 399,133
Large GWAS
multi-ancestry
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.04
p 2.0e-22
N 358,800
Major Consortium StudyLarge GWAS
multi-ancestry
Ware EB et al. “Genome-wide Association Study of 24-Hour Urinary Excretion of Calcium, Magnesium, and Uric Acid.” Mayo Clinic Proceedings. Innovations, Quality & Outcomes 3(4):448-460 (2019)
Allele C
OR 10.93
p 1.0e-8
N 6,462
Large GWAS
European
glomerular filtration rate
Stanzick KJ et al. “Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals.” Nature Communications 12(1):4350 (2021)
Allele T
OR 0.00
p 7.0e-68
N 1,201,930
Large GWAS
multi-ancestry
Liu H et al. “Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.” Nature Genetics 54(7):950-962 (2022)
Allele T
OR 16.75
p 6.0e-63
N 1,508,659
Large GWAS
multi-ancestry
Wuttke M et al. “A catalog of genetic loci associated with kidney function from analyses of a million individuals.” Nature Genetics 51(6):957-972 (2019)
Allele T
OR 0.01
p 2.0e-46
N 765,348
Large GWAS
multi-ancestry
Graham SE et al. “Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis.” Nature Communications 10(1):1847 (2019)
Allele T
OR 8.53
p 1.0e-17
N 350,514
Meta-analysisLarge GWAS
multi-ancestry
Morris AP et al. “Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.” Nature Communications 10(1):29 (2019)
Allele T
OR 0.53
p 5.0e-16
N 312,296
Large GWAS
multi-ancestry
vitamin D level
Revez JA et al. “Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.” Nature Communications 11(1):1647 (2020)
Allele T
OR —
β 0.038
p 6.0e-48
N 417,580
Large GWAS
European
Jiang X et al. “Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.” Nature Communications 9(1):260 (2018)
Allele T
OR 0.03
p 8.0e-23
N 79,366
Large GWAS
multi-ancestry
fibroblast growth factor 23 level
Robinson-Cohen C et al. “Genetic Variants Associated with Circulating Fibroblast Growth Factor 23.” Journal of the American Society of Nephrology : Jasn 29(10):2583-2592 (2018)
Allele T
OR 0.05
p 3.0e-24
N 16,624
Large GWAS
multi-ancestry
blood urea nitrogen amount
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele C
OR 0.03
p 7.0e-24
N 492,819
Large GWAS
multi-ancestry
Stanzick KJ et al. “Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals.” Nature Communications 12(1):4350 (2021)
Allele C
OR 0.01
p 8.0e-23
N 852,680
Large GWAS
European
serum creatinine amount, glomerular filtration rate
Pattaro C et al. “Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.” Nature Communications 7:10023 (2016)
Allele T
OR 0.01
p 9.0e-15
N 133,413
Large GWAS
multi-ancestry
vitamin D level, vitamin D dietary intake measurement
Jiang X et al. “Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.” Nature Communications 9(1):260 (2018)
Allele T
OR —
p 1.0e-14
N 39,868
Large GWAS
European
level of phosphoinositide-3-kinase-interacting protein 1 in blood
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.05
p 5.0e-13
N 47,745
Large GWAS
European
urate measurement
Cho C et al. “Large-scale cross-ancestry genome-wide meta-analysis of serum urate.” Nature Communications 15(1):3441 (2024)
Allele T
OR 0.02
p 3.0e-10
N 1,029,323
Meta-analysisLarge GWAS
multi-ancestry
alkaline phosphatase measurement
Chen VL et al. “Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology.” Nature Communications 12(1):816 (2021)
Allele C
OR 5.79
p 7.0e-9
N 390,964
Large GWAS
multi-ancestry
▶Research that mentions this SNP (1)
▶A mendelian randomization study on causal effects of 25(OH)vitamin D levels on attention deficit/hyperactivity disorderMeta-analysisN=133,650Lars Libuda et al.(2021)· European Journal of Nutrition
A mendelian randomization study on causal effects of 25(OH)vitamin D levels on attention deficit/hyperactivity disorder
Meta-analysisN=133,650Lars Libuda et al.(2021)· European Journal of Nutrition
A bidirectional two-sample Mendelian randomization study examining the causal relationship between 25-hydroxyvitamin D levels and attention-deficit/hyperactivity disorder (ADHD). Using 79,366 European individuals for vitamin D GWAS data and 19,099 ADHD cases with 34,194 controls, the study found no evidence of a causal effect of vitamin D on ADHD (IVW β = -0.043, p = 0.833) or reverse causality. Although rs12785878 showed a nominal association with increased ADHD risk at higher vitamin D levels (p = 0.024), this did not survive multiple testing correction.
Traits studied:Attention-deficit/hyperactivity disorder (ADHD)Vitamin D levels (25-hydroxyvitamin D)
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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