rs17277546
This is a 3 prime utr variant variant in the TRIM4 gene.
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
body height
Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele A
OR 0.03
p 4.0e-85
N 5,314,291
Large GWAS
European, Hispanic or Latin American, East Asian, African unspecified, South Asian
metabolite measurement
Suhre K et al. “Human metabolic individuality in biomedical and pharmaceutical research.” Nature 477(7362):54-60 (2011)
Allele A
OR 0.48
p 9.0e-40
N 2,820
Large GWAS
European
testosterone measurement
Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele A
OR 0.08
p 2.0e-36
N 322,594
Major Consortium StudyLarge GWAS
multi-ancestry
estrone measurement
Eriksson AL et al. “Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men.” The Journal of Clinical Endocrinology and Metabolism 103(3):991-1004 (2018)
Allele G
OR 3.59
p 6.0e-14
N 7,570
Large GWAS
European
hormone measurement
Zhai G et al. “Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.” Plos Genetics 7(4):e1002025 (2011)
Allele A
OR 0.11
p 2.0e-11
N 14,846
Large GWAS
European
About TRIM4
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternatively spliced transcript variants that encode different isoforms have been described.[provided by RefSeq, Jul 2010]
View all TRIM4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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