rs17314804

This is a intron variant variant in the MAML3 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

age at first birth measurement

Mills MC et al. “Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.” Nature Human Behaviour 5(12):1717-1730 (2021)

Allele T

OR 0.07

p 3.0e-12

N 542,901

Large GWAS

European

smoking cessation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele T

OR 0.01

p 3.0e-11

N 1,400,535

Large GWAS

European, East Asian, Hispanic or Latin American, African unspecified

About MAML3

Enables transcription coactivator activity. Involved in Notch signaling pathway and positive regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

View all MAML3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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