rs173365

This Japanese case-control study examined 12 SNPs in CRHR1 and CRHR2 genes in 173 major depressive disorder (MDD) patients, 180 panic disorder (PD) patients, and 285 healthy controls. SNP rs110402 in CRHR1 showed association with MDD (p=0.001, OR=1.81), as did rs242924 in CRHR1 for both MDD (p=0.013) and PD (p=0.022, OR=1.55). SNP rs3779250 in CRHR2 showed strong association with MDD (p=1.75e-11, OR=2.83). Haplotype analyses identified T-A-T-G-G and T-A haplotypes in CRHR1 associated with MDD, and C-C haplotype in CRHR2 associated with PD.

This gene-environment interaction study examined 460 women including FMR1 premutation carriers to test whether CRHR1 polymorphisms moderate the relationship between raising a child with Fragile X Syndrome and anxiety/depression symptoms. A significant interaction was identified between rs7209436 genotype and FXS child status in predicting social anxiety scores (P = 0.0001), suggesting that CRHR1 genetic variants influencing cortisol activation modulate anxiety responses to the stress of raising a child with FXS.

This gene-environment interaction study examined 422 African American adults (and validated findings in 199 Caucasian women) to assess how CRHR1 gene polymorphisms moderate the effect of child abuse on adult depression. The study found significant gene-environment interactions with multiple SNPs including rs110402 (P=.008) and a protective haplotype in intron 1 (P<.001), where individuals carrying protective alleles of rs110402 and rs7209436 showed markedly lower depression scores (BDI=10.22) despite moderate-to-severe childhood abuse, compared to those with common alleles (BDI=22.33-22.49).