rs17339836
This is a intron variant variant in the TNPO3 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Sjogren syndrome
Lessard CJ et al. “Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.” Nature Genetics 45(11):1284-92 (2013)
Allele T
OR 1.58
p 2.0e-16
N 2,370
Large GWAS
European
About TNPO3
The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Several protein-coding and non-coding transcript variants have been found for this gene. [provided by RefSeq, Apr 2020]
View all TNPO3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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