rs17421627
This is a intron variant variant in the LINC00461 gene.
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
photoreceptor cell layer thickness measurement
Currant H et al. “Sub-cellular level resolution of common genetic variation in the photoreceptor layer identifies continuum between rare disease and common variation.” Plos Genetics 19(2):e1010587 (2023)
Allele G
OR 1.15
p 3.0e-33
N 31,135
Large GWAS
European
ganglion thickness
Currant H et al. “Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images.” Plos Genetics 17(5):e1009497 (2021)
Allele G
OR 0.97
p 8.0e-27
N 31,434
Major Consortium StudyLarge GWAS
European
retinal layer thickness
Currant H et al. “Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images.” Plos Genetics 17(5):e1009497 (2021)
Allele G
OR 0.97
p 8.0e-27
N 31,434
Major Consortium StudyLarge GWAS
European
eye measurement
Ikram MK et al. “Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.” Plos Genetics 6(10):e1001184 (2010)
Allele G
OR 3.00
p 7.0e-16
N 15,358
Large GWAS
European
macular telangiectasia type 2
Bonelli R et al. “Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder.” Communications Biology 4(1):274 (2021)
Allele G
OR —
p 1.0e-16
N 4,676
Large GWAS
European
open-angle glaucoma
Han X et al. “Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci.” Nature Genetics 55(7):1116-1125 (2023)
Allele T
OR 0.09
p 8.0e-9
N 379,422
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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