rs17427960

This variant is located in the HOTTIP gene.

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Research that mentions this SNP (1)

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The association of lncRNA SNPs and SNPs‐environment interactions based on GWAS with HBV‐related HCC risk and progression
AssociationN=1,745Qing Liu et al.(2021)· Molecular Genetics & Genomic Medicine

This case-control study of 1,745 Southern Chinese subjects (643 HBV-related HCC patients, 549 CHB carriers, 553 HBV natural clearance subjects) identified 8 potentially functional lncRNA SNPs from two lncRNAs (lnc-ACACA-1 and lnc-RP11-150O12.3) located in HBV-related HCC GWAS susceptibility regions. The study found that rs9908998 in lnc-ACACA-1 significantly increased lymphatic metastasis risk (Adjusted OR = 1.95, 95% CI = 1.20-3.17), and that rs2275959, rs1008547, and rs11776545 in lnc-RP11-150O12.3 showed significant multiplicative and additive interactions with cancer family history on HBV-related HCC susceptibility, as well as associations with distant metastasis (Adjusted OR = 1.45, 95% CI = 1.06-1.97 for rs2275959; OR = 1.45, 95% CI = 1.06-1.98 for rs1008547; OR = 1.40, 95% CI = 1.03-1.91 for rs11776545).

Traits studied:Cancer embolusChronic hepatitis B (CHB)Distant metastasisHBV natural clearanceHepatitis B virus-related hepatocellular carcinoma (HBV-related HCC)Lymphatic metastasisTNM classification
PubMedDOIMetascience Observatory

About HOTTIP

This gene produces a long RNA in antisense to the HOXA gene cluster. This transcript may regulate expression of HOXA genes in cis. This gene is upregulated in tumors and is implicated in the promotion of cell proliferation. [provided by RefSeq, Dec 2017]

View all HOTTIP variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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