rs174529

This variant is located in the MYRF gene.

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GWAS Catalog Trait Associations (35)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

phosphatidylcholine (18:0/20:2, 20:0/18:2) measurement

Yin X et al. “Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci.” Nature Communications 13(1):1644 (2022)
Allele C
OR 0.36
p 4.0e-79
N 6,136
Large GWAS
European

triglycerides in very large VLDL measurement

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele T
OR 0.06
p 1.0e-50
N 136,016
Large GWAS
multi-ancestry

blood VLDL cholesterol amount

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele T
OR 0.06
p 8.0e-44
N 136,016
Large GWAS
multi-ancestry

total lipids in very large VLDL measurement

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele T
OR 0.06
p 2.0e-41
N 136,016
Large GWAS
multi-ancestry

free cholesterol in large VLDL measurement

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele T
OR 0.05
p 3.0e-39
N 136,016
Large GWAS
multi-ancestry

total lipids in medium VLDL

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele T
OR 0.05
p 2.0e-36
N 136,016
Large GWAS
multi-ancestry

free cholesterol in medium VLDL measurement

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele T
OR 0.05
p 1.0e-35
N 136,016
Large GWAS
multi-ancestry

triglyceride measurement, blood VLDL cholesterol amount, chylomicron amount

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele T
OR 0.05
p 4.0e-35
N 136,016
Large GWAS
multi-ancestry

total cholesterol in large VLDL

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele T
OR 0.05
p 9.0e-32
N 136,016
Large GWAS
multi-ancestry
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ClinVar annotation

Benign★★★☆
2 submitters1 publication
View on ClinVar →

About MYRF

This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

View all MYRF variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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