rs174534

This variant is located in the MYRF gene.

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GWAS Catalog Trait Associations (20)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

dihomo-gamma-linolenic acid measurement

Dorajoo R et al. “A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population.” Genes & Nutrition 10(6):53 (2015)
Allele G
OR 0.18
p 1.0e-29
N 1,361
Large GWAS
East Asian

heel bone mineral density

Morris JA et al. “An atlas of genetic influences on osteoporosis in humans and mice.” Nature Genetics 51(2):258-266 (2019)
Allele A
OR 0.02
p 3.0e-18
N 426,824
Large GWAS
European

neural cell adhesion molecule L1-like protein amount

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.04
p 7.0e-13
N 47,745
Large GWAS
European
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ClinVar annotation

Benign★★★☆
2 submitters1 publication
View on ClinVar →

About MYRF

This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

View all MYRF variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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