rs17454584

This is a downstream gene variant variant.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Eczematoid dermatitis, allergic rhinitis

Johansson Å et al. “Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.” Human Molecular Genetics 28(23):4022-4041 (2019)
Allele G
OR 1.08
p 2.0e-30
N 323,807
Major Consortium StudyLarge GWAS
European

asthma

Han Y et al. “Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.” Nature Communications 11(1):1776 (2020)
Allele G
OR 1.08
p 5.0e-25
N 303,859
Large GWAS
European
Olafsdottir TA et al. “Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis.” Nature Communications 11(1):393 (2020)
Allele G
OR 1.05
p 8.0e-12
N 771,388
Large GWAS
European
Ferreira MAR et al. “Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.” American Journal of Human Genetics 104(4):665-684 (2019)
Allele G
OR 1.08
p 2.0e-21
N 341,215
Large GWAS
European

adult onset asthma

Ferreira MAR et al. “Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.” American Journal of Human Genetics 104(4):665-684 (2019)
Allele G
OR 1.05
p 2.0e-10
N 327,253
Large GWAS
European

allergic sensitization measurement

Bønnelykke K et al. “Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.” Nature Genetics 45(8):902-906 (2013)
Allele G
OR 1.15
p 6.0e-10
N 15,845
Meta-analysisLarge GWAS
European

asthma, age at onset

Ferreira MAR et al. “Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.” American Journal of Human Genetics 104(4):665-684 (2019)
Allele G
OR 1.07
p 5.0e-8
N 28,835
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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