rs174568

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GWAS Catalog Trait Associations (44)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Red cell distribution width

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.06
p 4.0e-93
N 380,796
Major Consortium StudyLarge GWAS
European

low density lipoprotein cholesterol measurement, physical activity

Kilpeläinen TO et al. “Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.” Nature Communications 10(1):376 (2019)
Allele T
OR —
p 2.0e-48
N 109,688
Large GWAS
multi-ancestry

level of Phosphatidylinositol (18:0_18:2) in blood serum

Tabassum R et al. “Lipidome- and Genome-Wide Study to Understand Sex Differences in Circulatory Lipids.” Journal of the American Heart Association 11(19):e027103 (2022)
Allele T
OR 0.31
p 3.0e-43
N 4,642
Large GWAS
European

1-dihomo-linoleoyl-GPC (20:2) measurement

Yin X et al. “Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci.” Nature Communications 13(1):1644 (2022)
Allele T
OR 0.25
p 4.0e-41
N 6,136
Large GWAS
European

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele T
OR 0.03
p 9.0e-36
N 455,180
Large GWAS
Hispanic or Latin American

serum metabolite level

Feofanova EV et al. “A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos.” American Journal of Human Genetics 107(5):849-863 (2020)
Allele C
OR 0.30
p 7.0e-34
N 3,926
Large GWAS
Hispanic or Latin American
Li Y et al. “Genome-Wide Association Studies of Metabolites in Patients with CKD Identify Multiple Loci and Illuminate Tubular Transport Mechanisms.” Journal of the American Society of Nephrology : Jasn 29(5):1513-1524 (2018)
Allele C
OR 0.24
p 3.0e-8
N 1,143
Large GWAS
European

level of Phosphatidylcholine (17:0_18:2) in blood serum

Tabassum R et al. “Lipidome- and Genome-Wide Study to Understand Sex Differences in Circulatory Lipids.” Journal of the American Heart Association 11(19):e027103 (2022)
Allele T
OR 0.25
p 3.0e-29
N 4,642
Large GWAS
European
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Research that mentions this SNP (1)

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Single nucleotide polymorphisms within MicroRNAs, MicroRNA targets, and MicroRNA biogenesis genes and their impact on colorectal cancer survival
AssociationN=2,288Lila E. Mullany et al.(2017)· Genes, Chromosomes and Cancer

A candidate gene study of 1115 colorectal cancer cases and 1173 controls examined associations between 565 SNPs in microRNA genes, miRNA target genes, and miRNA biogenesis genes with colorectal cancer survival. Seven SNPs remained significantly associated with survival after multiple comparison adjustment: rs12140 (ADAMTS1, HRR=0.44, protective), and six SNPs associated with increased mortality risk including rs6598964 (LIN28A, HRR=2.26) which paradoxically decreased cancer risk (OR=0.77) but increased mortality. Five SNPs were also associated with altered mRNA expression levels.

Traits studied:Colorectal cancer riskColorectal cancer survivalmRNA expression
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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