rs174594

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GWAS Catalog Trait Associations (20)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of Phosphatidylcholine (18:0_18:2) in blood serum

Ottensmann L et al. “Genome-wide association analysis of plasma lipidome identifies 495 genetic associations.” Nature Communications 14(1):6934 (2023)
Allele C
OR 0.25
p 8.0e-49
N 7,174
Large GWAS
European

cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele A
OR 0.05
p 1.0e-38
N 136,016
Large GWAS
multi-ancestry

cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele A
OR 0.05
p 3.0e-38
N 136,016
Large GWAS
multi-ancestry

level of Phosphatidylcholine (15:0_18:2) in blood serum

Tabassum R et al. “Lipidome- and Genome-Wide Study to Understand Sex Differences in Circulatory Lipids.” Journal of the American Heart Association 11(19):e027103 (2022)
Allele C
OR 0.34
p 2.0e-30
N 2,624
Large GWAS
European

level of Phosphatidylcholine (17:0_18:2) in blood serum

Tabassum R et al. “Lipidome- and Genome-Wide Study to Understand Sex Differences in Circulatory Lipids.” Journal of the American Heart Association 11(19):e027103 (2022)
Allele C
OR 0.30
p 5.0e-26
N 2,624
Large GWAS
European

phospholipids:total lipids ratio, blood VLDL cholesterol amount

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele A
OR 0.04
p 1.0e-20
N 136,016
Large GWAS
multi-ancestry

acne

Teder-Laving M et al. “Genome-wide meta-analysis identifies novel loci conferring risk of acne vulgaris.” European Journal of Human Genetics : Ejhg 32(9):1136-1143 (2024)
Allele C
OR 1.08
p 4.0e-14
N 399,413
Meta-analysisLarge GWAS
European

colorectal cancer

Tanikawa C et al. “GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.” Carcinogenesis 39(5):652-660 (2018)
Allele A
OR 1.13
p 2.0e-13
N 33,870
Large GWAS
East Asian

serum metabolite level

Li Y et al. “Genome-Wide Association Studies of Metabolites in Patients with CKD Identify Multiple Loci and Illuminate Tubular Transport Mechanisms.” Journal of the American Society of Nephrology : Jasn 29(5):1513-1524 (2018)
Allele A
OR 0.30
p 5.0e-13
N 1,143
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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