rs1758632

This variant is located in the UBAP2 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

prostate carcinoma, type 2 diabetes mellitus

Ray D et al. “A powerful method for pleiotropic analysis under composite null hypothesis identifies novel shared loci between Type 2 Diabetes and Prostate Cancer.” Plos Genetics 16(12):e1009218 (2020)

Allele C

OR —

p 1.0e-12

N 801,624

Large GWAS

European

type 2 diabetes mellitus

Xue A et al. “Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.” Nature Communications 9(1):2941 (2018)

Allele C

OR 0.05

p 1.0e-9

N 659,316

Large GWAS

multi-ancestry

About UBAP2

The protein encoded by this gene contains a UBA (ubiquitin associated) domain, which is characteristic of proteins that function in the ubiquitination pathway. This gene may show increased expression in the adrenal gland and lymphatic tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

View all UBAP2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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