rs1759645

This is a regulatory region variant variant.

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body height

Chiou JS et al. “Your height affects your health: genetic determinants and health-related outcomes in Taiwan.” Bmc Medicine 20(1):250 (2022)
Allele C
OR 0.09
p 4.0e-30
N 67,452
Large GWAS
East Asian
Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele C
OR 0.06
p 1.0e-11
N 77,890
Large GWAS
South Asian
Fernández-Rhodes L et al. “Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium.” Hgg Advances 3(2):100099 (2022)
Allele C
OR 0.06
p 3.0e-28
N 59,771
Major Consortium StudyLarge GWAS
Hispanic or Latin American
Berndt SI et al. “Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.” Nature Genetics 45(5):501-12 (2013)
Allele C
OR 1.29
p 5.0e-15
N 16,196
Meta-analysisLarge GWAS
European

age at first birth measurement, uterine fibroid

Xiao C et al. “Genetic contribution of reproductive traits to risk of uterine leiomyomata: a large-scale, genome-wide, cross-trait analysis.” American Journal of Obstetrics and Gynecology 230(4):438.e1-438.e15 (2024)
Allele T
OR —
p 3.0e-11
N 721,737
Large GWAS
European

BMI-adjusted waist circumference

Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)
Allele C
OR 0.03
p 8.0e-11
N 160,475
Meta-analysisLarge GWAS
multi-ancestry

body height at birth

Yang XL et al. “Three Novel Loci for Infant Head Circumference Identified by a Joint Association Analysis.” Frontiers in Genetics 10:947 (2019)
Allele T
OR 0.05
p 7.0e-10
N 182,902
Large GWAS
European

birth weight

Yang XL et al. “Three Novel Loci for Infant Head Circumference Identified by a Joint Association Analysis.” Frontiers in Genetics 10:947 (2019)
Allele T
OR 0.03
p 1.0e-9
N 182,902
Large GWAS
European

BMI-adjusted hip circumference

Shungin D et al. “New genetic loci link adipose and insulin biology to body fat distribution.” Nature 518(7538):187-196 (2015)
Allele T
OR 0.03
p 9.0e-9
N 143,480
Large GWAS
multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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