rs17600642
This variant is located in the ADAMTS14 gene.
▶Research that mentions this SNP (1)
▶Propensity score‐based nonparametric test revealing genetic variants underlying bipolar disorderMethodsN=5,002Yuan Jiang et al.(2011)· Genetic Epidemiology
This methods paper presents a propensity score-based nonparametric test for genetic association that adjusts for covariates using genomic propensity scores. Applied to 1,998 bipolar disorder cases and 3,004 controls from the Wellcome Trust Case Control Consortium, the method identified three SNPs on chromosome 16 (rs2387823, rs1344485, rs11647459; p < 5×10⁻⁷) in strong linkage disequilibrium near RPGRIP1L that were missed by standard unadjusted methods, demonstrating that covariate-adjusted approaches can reveal genetic variants underlying bipolar disorder.
About ADAMTS14
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016]
View all ADAMTS14 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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