rs17609240

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

leukocyte quantity

Soranzo N et al. “A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.” Nature Genetics 41(11):1182-90 (2009)
Allele G
OR 0.02
p 9.0e-9
N 4,627
Meta-analysisMajor Consortium Study
European
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Research that mentions this SNP (1)

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Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network
AssociationN=13,923Crosslin DR et al.(2012)· Human Genetics

This GWAS of 13,923 subjects identified ancestry-specific genetic variants associated with white blood cell count. In African ancestry individuals, the DARC gene variants rs2814778 (β=1.35, p=6.71e-55) and rs12075 (β=1.27, p=4.92e-24) showed genome-wide significant associations. In European ancestry individuals, variants in the 17q21.1 region tagging GSDMA, PSMD3, and MED24 were associated with WBC (rs3859192: β=0.14, p=1.75e-12; rs4065321: β=0.14, p=3.47e-11), with evidence of pleiotropy with asthma-associated variants.

Traits studied:Basophil countEosinophil countLymphocyte countMonocyte countNeutrophil countWhite blood cell count
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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