rs17619601
This is a intron variant variant in the FLT1 gene.
▶Research that mentions this SNP (1)
▶Interactions between environmental factors and polymorphisms in angiogenesis pathway genes in esophageal adenocarcinoma risk: A case‐only studyAssociationN=335Rihong Zhai et al.(2012)· Cancer
Case-only study of 335 esophageal adenocarcinoma (EA) patients examining gene-environment interactions in angiogenesis pathway genes. Identified significant interactions between SNPs in HIF1AN, TSC2, VEGFR1, PDGFRA, and PDGFRB with GERD, smoking, and BMI. Notable findings include rs2295778 (HIF1AN)-GERD with OR=2.23 (p=0.0005) and dose-response effects with cumulative risk genotypes (OR=12.07 for >5 risk genotypes vs BMI≥25).
About FLT1
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
View all FLT1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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