rs1763500
This variant is located in the SGK1 gene.
▶Research that mentions this SNP (1)
▶Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women’s Health Initiative SHARe StudyAssociationN=11,687Digna R. Velez Edwards et al.(2013)· Human Genetics
A genome-wide gene-environment interaction study examined 8,203 African-American and 3,484 Hispanic postmenopausal women from the Women's Health Initiative SHARe GWAS for SNP interactions with lifestyle factors (smoking, diet, physical activity, alcohol) on BMI and waist-to-hip ratio. The strongest BMI gene-environment interaction across cohorts was rs10133840 with smoking (beta=-0.01, P=3.81×10^-7), and the strongest WHR interaction in African-Americans was rs9557704 (ITGBL1) with dietary energy intake (beta=-0.04, P=2.17×10^-7).
About SGK1
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
View all SGK1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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