rs17643057

▶

GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

balding measurement

Heilmann-Heimbach S et al. “Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness.” Nature Communications 8:14694 (2017)
Allele G
OR 0.21
p 3.0e-25
N 22,518
Meta-analysisLarge GWAS
European

heart failure

Lee DSM et al. “Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.” Nature Genetics 57(4):829-838 (2025)
Allele A
OR 0.02
p 2.0e-8
N 2,358,556
Large GWAS
multi-ancestry
▶

Research that mentions this SNP (1)

▶
The genetics of antipsychotic induced tremors: A genome‐wide pathway analysis on the STEP‐BD SCP sample
AssociationN=409Antonio Drago et al.(2011)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Genome-wide pathway analysis of 409 bipolar patients treated with antipsychotics identified molecular pathways significantly associated with antipsychotic-induced tremors/extrapyramidal symptoms (EPS). While no single SNPs reached GWAS significance (p=4.2×10⁻⁷), pathway analysis revealed significant associations with pathways related to oxidative stress, cell survival (hsa04930, hsa04115), cell movement (hsa04512, hsa04510), and lipid metabolism (hsa00561, hsa03320) at p=0.0009-0.0019. The top individual SNPs showed beta coefficients ranging from -0.25 to 1.11, suggesting complex genetic architecture underlying antipsychotic-induced motor side effects.

Traits studied:Antipsychotic-induced akathisiaAntipsychotic-induced extrapyramidal symptomsAntipsychotic-induced parkinsonismAntipsychotic-induced tardive dyskinesiaAntipsychotic-induced tremors
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…