rs17650
This is a variant in the ORM1 gene that changes a arginine to an glutamine.
▶ClinVar annotation
▶Research that mentions this SNP (1)
▶Influence of ORM1 polymorphisms on the maintenance stable warfarin dosageAssociationN=191Lian Sheng Wang et al.(2013)· European Journal of Clinical Pharmacology
This study examined 191 Chinese patients on warfarin therapy to determine whether the ORM1 rs17650 polymorphism influences warfarin maintenance dosage. Results showed that warfarin dose was significantly correlated with VKORC1 rs7294, CYP2C9 rs1057910, and ORM1 rs17650 polymorphisms (all P<0.05), with these three genes explaining 24% of dosage variation. ORM1 *S/*S and *F1/*S carriers required approximately 10-17% lower warfarin doses compared to wild-type *F1/*F1 patients.
About ORM1
This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]
View all ORM1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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