rs1768208

This is a intron variant variant in the MOBP gene.

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Research that mentions this SNP (1)

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Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci
AssociationN=437Mariet Allen et al.(2016)· Acta Neuropathologica

A study of 175 PSP (progressive supranuclear palsy) cases examining effects of GWAS-identified risk variants on brain gene expression, CpG methylation, and neuropathology. PSP risk SNPs rs8070723, rs242557, and rs1768208 were associated with altered brain levels of LRRC37A4, ARL17B, ARL17A, and MOBP. Meta-analysis confirmed highly significant associations for rs8070723 with LRRC37A4 and rs1768208 with MOBP. Risk alleles also associated with increased tau neuropathology including coiled bodies and tau threads, suggesting these variants influence PSP risk through effects on gene expression and tau pathology.

Traits studied:Neurofibrillary tanglesOligodendroglial coiled bodiesProgressive supranuclear palsy (PSP)Tau neuropathologyTau threadsTufted astrocytes
PubMedDOIMetascience Observatory

About MOBP

Predicted to be a structural constituent of myelin sheath. Predicted to be involved in nervous system development. Predicted to be located in mitochondrion and perinuclear region of cytoplasm. Implicated in frontotemporal dementia. [provided by Alliance of Genome Resources, Jul 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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