rs177852

This is a intron variant variant in the TTC6 gene.

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Research that mentions this SNP (1)

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Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD
AssociationN=4,048Hansel NN et al.(2013)· Human Genetics

A genome-wide association study of lung function decline in 4,048 European-American smokers with mild COPD identified two novel loci associated with accelerated FEV1 decline over 5 years. Two intergenic SNPs on chromosome 10 (rs10761570, rs7911302, p<9.45×10⁻⁸) and one SNP on chromosome 14 (rs177852, p<9.45×10⁻⁸) met genome-wide significance. Imputation revealed additional significant variants (rs10761571, rs7896712, p=3.7×10⁻⁸). Functional studies demonstrated novel expression of ANK3, TMEM26, and FOXA1 in lung tissue with differential expression between COPD patients and smokers without obstruction.

Traits studied:COPD (Chronic Obstructive Pulmonary Disease)Chronic airflow obstructionLung function decline (FEV1)
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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