rs1785437
This is a intron variant variant in the TRPM2 gene.
▶ClinVar annotation
▶Research that mentions this SNP (1)
▶Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorderAssociationN=446Chun Xu et al.(2006)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Case-control study examining seven SNPs in the TRPM2 gene and bipolar disorder in 446 Caucasian subjects. SNP rs1618355 in intron 18 showed significant association with bipolar disorder overall (P < 7.0×10⁻⁵; OR = 2.60), BD-I (P < 7.0×10⁻⁵; OR = 2.48), and BD-II (P = 7.0×10⁻⁵; OR = 2.88). A seven-marker at-risk haplotype (T-T-T-C-T-T-A) was significantly more frequent in BD patients (12.0%) versus controls (0.9%; P = 2.3×10⁻¹²).
About TRPM2
The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]
View all TRPM2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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