rs17860115
This variant is located in the IFNAR2 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
COVID-19
Kousathanas A et al. “Whole-genome sequencing reveals host factors underlying critical COVID-19.” Nature 607(7917):97-103 (2022)
Allele A
OR 1.20
p 1.0e-21
N 48,880
Large GWAS
European
About IFNAR2
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45. [provided by RefSeq, Jul 2020]
View all IFNAR2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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