rs1786929

This variant is located in the CTNNA3 gene.

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Research that mentions this SNP (1)

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Polymorphisms in recent GWA identified asthma genes CA10, SGK493, and CTNNA3 are associated with disease severity and treatment response in childhood asthma
AssociationN=564Petra Perin et al.(2014)· Immunogenetics

Association study of 288 children with asthma and 276 controls investigating SNPs from recent GWA studies. Found rs967676 (CA10, p=0.001, OR=1.88) and rs1440095 (SGK493, p=0.011, OR=2.49 in nonatopic asthma) associated with asthma risk. Additionally, rs967676 and rs1786929 (CTNNA3) were associated with disease severity and glucocorticoid treatment response, with rs1786929 showing better ICS response (p=0.022).

Traits studied:Airway obstructionAsthmaAtopic asthmaBronchial hyperreactivityChildhood asthmaNonatopic asthmaPulmonary functionResponse to glucocorticoidsResponse to inhaled corticosteroids
PubMedDOIMetascience Observatory

About CTNNA3

This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

View all CTNNA3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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