rs1799972
This is a protein-altering variant in the OPRM1 gene.
▶Research that mentions this SNP (2)
▶The relationship between polymorphisms of BDNFOS and BDNF genes and heroin addiction in the Han Chinese populationReviewTianbo Jin et al.(2016)· The Journal of Gene Medicine
This review examines neurogenetic and neuropharmacological correlates of opioid use disorder (OUD) with emphasis on ancestry-specific genetic risk profiles. The paper identifies multiple genes involved in the reward pathway (DRD2, DRD3, DRD4, OPRM1, OPRK1, OPRD1, BDNF, NRXN3, COMT, SLC6A4, KCNC1, KCNG2) and their variants associated with OUD susceptibility and treatment response across different ethnic populations, highlighting critical research disparities where African Americans and Hispanics have been underrepresented in genetic association studies.
▶Novel exonic μ‐opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependenceAssociationN=190Rachel J. Smith et al.(2005)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Population genetics study of OPRM1 and COMT gene variants in the Chaco province of Argentina. Genotyped 11 SNPs in 54 individuals from Misión Nueva Pompeya and compared with published data from Resistencia (n=109) and Wichí native communities (n=27). Found significant population differentiation at Fst values ranging from 1.507% to 2.744% between populations, with notable variation in pain-related and dopaminergic genes that could inform personalized pain management strategies.
About OPRM1
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]
View all OPRM1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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