OPRM1
opioid receptor mu 1
Pharmacogene
Summary
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]
Known Variants463 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1583105193 | 6:154,331,614 | C/T | — | drug response |
| rs1326499420 | 6:154,331,727 | A/C | — | drug response |
| rs115788842 | 6:154,331,770 | T/A | — | drug response |
| rs1583105350 | 6:154,331,796 | A/G | — | drug response |
| rs1583105355 | 6:154,331,800 | G/A | — | drug response |
| rs1583105431 | 6:154,331,850 | G/A | — | drug response |
| rs1583105433 | 6:154,331,853 | T/A | — | drug response |
| rs1583105485 | 6:154,331,895 | A/G | — | drug response |
| rs1583105621 | 6:154,331,960 | C/T | — | drug response |
| rs1368893702 | 6:154,331,963 | G/A | — | drug response |
| rs1583105642 | 6:154,331,964 | C/T | — | drug response |
| rs1583105657 | 6:154,331,975 | A/T | — | drug response |
| rs1583105979 | 6:154,332,099 | A/T | — | drug response |
| rs1583106074 | 6:154,332,143 | C/T | — | drug response |
| rs1583106084 | 6:154,332,152 | G/T | — | drug response |
| rs1583106153 | 6:154,332,164 | G/T | — | drug response |
| rs1583106204 | 6:154,332,204 | G/T | — | drug response |
| rs769686797 | 6:154,332,223 | G/C | — | drug response |
| rs1074287 | 6:154,348,809 | A/C | — | — |
| rs1583168957 | 6:154,360,166 | C/A | — | drug response |
| rs1583168963 | 6:154,360,168 | T/C | — | drug response |
| rs1583168972 | 6:154,360,170 | C/A | — | drug response |
| rs546524303 | 6:154,360,173 | G/A | — | drug response |
| rs571470402 | 6:154,360,174 | A/G | — | drug response |
| rs1583169018 | 6:154,360,175 | T/C | — | drug response |
| rs747345350 | 6:154,360,279 | C/A | — | drug response |
| rs1583169368 | 6:154,360,285 | C/T | — | drug response |
| rs1583169385 | 6:154,360,286 | C/A | — | drug response |
| rs1312664080 | 6:154,360,323 | G/A | — | drug response |
| rs1247954412 | 6:154,360,399 | C/A | — | drug response |
| rs1583169899 | 6:154,360,415 | T/A | — | drug response |
| rs1583169988 | 6:154,360,443 | G/T | — | drug response |
| rs1583170034 | 6:154,360,452 | C/T | — | drug response |
| rs1421882124 | 6:154,360,455 | T/C | — | drug response |
| rs1583170107 | 6:154,360,471 | G/T | — | drug response |
| rs1562384714 | 6:154,360,484 | G/T | — | drug response |
| rs1230347496 | 6:154,360,489 | G/A | — | drug response |
| rs6912029 | 6:154,360,508 | G/T | — | drug response |
| rs1583170298 | 6:154,360,513 | G/A | — | drug response |
| rs1469997583 | 6:154,360,532 | C/T | — | drug response |
| rs1583170659 | 6:154,360,571 | G/A | — | drug response |
| rs1583170710 | 6:154,360,575 | G/A | — | drug response |
| rs1583170716 | 6:154,360,578 | C/T | — | drug response |
| rs1583170728 | 6:154,360,581 | T/A | — | drug response |
| rs1465337438 | 6:154,360,609 | C/A | — | drug response |
| rs370868117 | 6:154,360,645 | C/T | — | drug response |
| rs41292890 | 6:154,360,655 | C/T | — | likely benign |
| rs1583171311 | 6:154,360,660 | C/T | — | drug response |
| rs199648369 | 6:154,360,666 | C/T | — | drug response |
| rs1583171446 | 6:154,360,673 | C/T | — | drug response |
| rs1297476429 | 6:154,360,678 | C/A | — | drug response |
| rs747772652 | 6:154,360,686 | A/G | — | drug response |
| rs1223121173 | 6:154,360,692 | G/A | — | likely benign |
| rs1799972 | 6:154,360,696 | C/G | missense variant | — |
| rs62436460 | 6:154,360,700 | C/G | — | likely benign |
| rs745863104 | 6:154,360,706 | C/T | — | drug response |
| rs577345039 | 6:154,360,732 | C/T | — | drug response |
| rs1583172139 | 6:154,360,753 | C/A | — | drug response |
| rs1799971 | 6:154,360,797 | A/G | missense variant | drug response |
| rs200964660 | 6:154,360,820 | G/A | — | likely benign |
| rs779965433 | 6:154,360,839 | G/A | — | uncertain significance |
| rs1583173066 | 6:154,360,861 | C/T | — | drug response |
| rs1482103571 | 6:154,360,872 | C/T | — | drug response |
| rs1583173231 | 6:154,360,873 | C/T | — | drug response |
| rs1583173318 | 6:154,360,883 | C/T | — | drug response |
| rs201310502 | 6:154,360,894 | C/T | — | drug response |
| rs1583173471 | 6:154,360,902 | G/C | — | drug response |
| rs1583173482 | 6:154,360,903 | C/T | — | drug response |
| rs200915701 | 6:154,360,922 | C/T | — | drug response |
| rs1190969003 | 6:154,360,947 | C/T | — | drug response |
| rs1583174062 | 6:154,360,985 | G/A | — | drug response |
| rs377704466 | 6:154,360,987 | G/A | — | drug response |
| rs1583174701 | 6:154,361,041 | C/A | — | drug response |
| rs1583174793 | 6:154,361,056 | G/A | — | drug response |
| rs1583174969 | 6:154,361,087 | G/A | — | drug response |
| rs1562387533 | 6:154,361,090 | G/C | — | drug response |
| rs1583175062 | 6:154,361,091 | G/A | — | drug response |
| rs510769 | 6:154,362,019 | C/T | intron variant | — |
| rs634479 | 6:154,364,440 | A/G | intron variant | — |
| rs524731 | 6:154,375,092 | C/A | intron variant | — |
| rs696523 | 6:154,376,542 | A/C | intron variant | — |
| rs9478500 | 6:154,378,223 | T/C | intron variant | — |
| rs3823010 | 6:154,379,152 | G/A | intron variant | — |
| rs495491 | 6:154,382,542 | A/G | intron variant | — |
| rs3778150 | 6:154,383,658 | T/C | intron variant | — |
| rs9478503 | 6:154,392,675 | T/C | intron variant | — |
| rs3778151 | 6:154,393,680 | T/C | intron variant | — |
| rs3778157 | 6:154,405,701 | T/C | intron variant | — |
| rs1583453568 | 6:154,407,516 | T/C | — | drug response |
| rs1583453631 | 6:154,407,521 | A/T | — | drug response |
| rs1583454341 | 6:154,407,633 | T/G | — | drug response |
| rs1340096837 | 6:154,407,639 | A/C | — | drug response |
| rs1583454446 | 6:154,407,640 | A/C | — | drug response |
| rs1583454910 | 6:154,407,721 | A/T | — | drug response |
| rs1583454933 | 6:154,407,724 | C/A | — | drug response |
| rs1583454962 | 6:154,407,731 | C/A | — | drug response |
| rs1583455028 | 6:154,407,752 | T/A | — | drug response |
| rs1260131147 | 6:154,407,770 | A/G | — | drug response |
| rs1583455134 | 6:154,407,779 | A/G | — | drug response |
| rs1583455554 | 6:154,407,864 | A/G | — | drug response |
Showing 100 of 463 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.