rs1074287
This variant is located in the OPRM1 gene.
▶Research that mentions this SNP (1)
▶Response to Methadone Maintenance Treatment is Associated with the MYOCD and GRM6 GenesAssociationN=116Francina Fonseca et al.(2010)· Molecular Diagnosis & Therapy
This case-control association study examined 116 opioid-dependent patients in methadone maintenance treatment (MMT) to identify genetic variants associated with treatment response. The study found significant epistatic interactions between rs1714984 (MYOCD) and rs953741 (GRM6), where carriers of the A allele at rs1714984 combined with the AG genotype at rs953741 showed increased risk of being nonresponders (OR=10.83, 95% CI 2.52-46.66, p=0.006). The study also identified rs1861591 (CRY1) as individually associated with nonresponder status (OR=2.99, p=0.035), though this did not survive multiple testing correction.
About OPRM1
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]
View all OPRM1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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