Trait
SNPs associated with Substance-Related Disorder
766 genetic variants across 170 genes have been associated with Substance-Related Disorder in published research. Key genes include ACSS3, ACTN2, ADGRL3.
Associated variants766 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs6589386 | — | GWAS association (p=2.0e-26) | Meta-analysis |
| rs1813006 | — | GWAS association (p=3.0e-12) | Meta-analysis |
| rs17602038 | LOC105369501 | GWAS association (p=7.0e-12) | Meta-analysis |
| rs3114045 | — | GWAS association (p=2.0e-10) | Meta-analysis |
| rs28567725 | FTO | GWAS association (p=3.0e-10) | Meta-analysis |
| rs1260326 | GCKR | GWAS association (p=8.0e-10) | Meta-analysis |
| rs1662031 | — | GWAS association (p=1.0e-09) | Meta-analysis |
| rs570436 | — | GWAS association (p=1.0e-09) | Meta-analysis |
| rs6795772 | — | GWAS association (p=2.0e-09) | Meta-analysis |
| rs10083370 | PPP1R13B | GWAS association (p=2.0e-09) | Meta-analysis |
| rs1475064 | — | GWAS association (p=3.0e-09) | Meta-analysis |
| rs2860846 | — | GWAS association (p=3.0e-09) | Meta-analysis |
| rs1937455 | — | GWAS association (p=8.0e-09) | Meta-analysis |
| rs2717054 | — | GWAS association (p=2.0e-08) | Meta-analysis |
| rs55855024 | — | GWAS association (p=2.0e-08) | Meta-analysis |
| rs7073987 | — | GWAS association (p=2.0e-08) | Meta-analysis |
| rs864882 | RABEPK | GWAS association (p=3.0e-08) | Meta-analysis |
| rs2424952 | — | GWAS association (p=3.0e-08) | Meta-analysis |
| rs2861190 | — | GWAS association (p=4.0e-08) | Meta-analysis |
| rs12808482 | DRD2 | GWAS association (p=1.0e-14) | Major Consortium Study |
| rs11642015 | FTO | GWAS association (p=6.0e-13) | Major Consortium Study |
| rs6446268 | RHOA | GWAS association (p=1.0e-12) | Major Consortium Study |
| rs1578022 | — | GWAS association (p=1.0e-11) | Major Consortium Study |
| rs12031120 | — | GWAS association (p=1.0e-28) | Large GWAS |
| rs1116313 | — | GWAS association (p=2.0e-28) | Large GWAS |
| rs12731986 | — | GWAS association (p=2.0e-28) | Large GWAS |
| rs1076563 | — | GWAS association (p=7.0e-28) | Large GWAS |
| rs13107325 | SLC39A8 | GWAS association (p=8.0e-28) | Large GWAS |
| rs9812360 | RHOA | GWAS association (p=1.0e-27) | Large GWAS |
| rs7122246 | DRD2 | GWAS association (p=9.0e-26) | Large GWAS |
| rs2734838 | DRD2 | GWAS association (p=3.0e-24) | Large GWAS |
| rs56137030 | FTO | GWAS association (p=4.0e-24) | Large GWAS |
| rs6794924 | IHO1 | GWAS association (p=4.0e-22) | Large GWAS |
| rs7519259 | — | GWAS association (p=5.0e-22) | Large GWAS |
| rs1229984 | ADH1B | GWAS association (p=3.0e-21) | Large GWAS |
| rs1944678 | — | GWAS association (p=4.0e-21) | Large GWAS |
| rs175979 | — | GWAS association (p=2.0e-20) | Large GWAS |
| rs6421482 | PDE4B | GWAS association (p=2.0e-20) | Large GWAS |
| rs10736470 | — | GWAS association (p=3.0e-20) | Large GWAS |
| rs61903076 | LOC107984390 | GWAS association (p=4.0e-20) | Large GWAS |
| rs7528128 | — | GWAS association (p=9.0e-20) | Large GWAS |
| rs112991785 | LOC107984390 | GWAS association (p=2.0e-19) | Large GWAS |
| rs4536858 | LAMB2P1 | GWAS association (p=2.0e-19) | Large GWAS |
| rs281264 | SEMA6D | GWAS association (p=3.0e-19) | Large GWAS |
| rs34333163 | — | GWAS association (p=2.0e-18) | Large GWAS |
| rs201401067 | — | GWAS association (p=1.0e-17) | Large GWAS |
| rs9869256 | BSN | GWAS association (p=2.0e-17) | Large GWAS |
| rs7937768 | — | GWAS association (p=4.0e-17) | Large GWAS |
| rs281280 | SEMA6D | GWAS association (p=4.0e-17) | Large GWAS |
| rs71559024 | ZNF391 | GWAS association (p=4.0e-17) | Large GWAS |
| rs34953377 | ZNF184 | GWAS association (p=5.0e-17) | Large GWAS |
| rs621271 | — | GWAS association (p=5.0e-17) | Large GWAS |
| rs11772832 | CNOT4 | GWAS association (p=6.0e-17) | Large GWAS |
| rs2718167 | CNOT4 | GWAS association (p=7.0e-17) | Large GWAS |
| rs10783447 | SLC4A8 | GWAS association (p=1.0e-16) | Large GWAS |
| rs61799396 | PDE4B | GWAS association (p=2.0e-16) | Large GWAS |
| rs12729364 | — | GWAS association (p=2.0e-16) | Large GWAS |
| rs2678892 | VRK2 | GWAS association (p=2.0e-16) | Large GWAS |
| rs10783453 | — | GWAS association (p=2.0e-16) | Large GWAS |
| rs55667828 | SCAI | GWAS association (p=3.0e-16) | Large GWAS |
| rs7103679 | DRD2 | GWAS association (p=3.0e-16) | Large GWAS |
| rs11380742 | — | GWAS association (p=3.0e-16) | Large GWAS |
| rs35706352 | — | GWAS association (p=4.0e-16) | Large GWAS |
| rs3774800 | — | GWAS association (p=7.0e-16) | Large GWAS |
| rs9646181 | SEMA6D | GWAS association (p=1.0e-15) | Large GWAS |
| rs2509377 | NCAM1 | GWAS association (p=1.0e-15) | Large GWAS |
| rs2678898 | VRK2 | GWAS association (p=2.0e-15) | Large GWAS |
| rs13196692 | ZNF184 | GWAS association (p=2.0e-15) | Large GWAS |
| rs13191038 | GPX6 | GWAS association (p=3.0e-15) | Large GWAS |
| rs2189010 | FOXP2 | GWAS association (p=3.0e-15) | Large GWAS |
| rs79068167 | — | GWAS association (p=3.0e-15) | Large GWAS |
| rs12564578 | PDE4B | GWAS association (p=4.0e-15) | Large GWAS |
| rs640052 | — | GWAS association (p=4.0e-15) | Large GWAS |
| rs11783093 | — | GWAS association (p=6.0e-15) | Large GWAS |
| rs11791724 | WDR38 | GWAS association (p=7.0e-15) | Large GWAS |
| rs11591603 | — | GWAS association (p=7.0e-15) | Large GWAS |
| rs2471851 | DRD2 | GWAS association (p=8.0e-15) | Large GWAS |
| rs8060511 | — | GWAS association (p=1.0e-14) | Large GWAS |
| rs4851030 | — | GWAS association (p=1.0e-14) | Large GWAS |
| rs1155397 | — | GWAS association (p=1.0e-14) | Large GWAS |
| rs12577005 | NCAM1 | GWAS association (p=2.0e-14) | Large GWAS |
| rs647905 | — | GWAS association (p=2.0e-14) | Large GWAS |
| rs6456785 | — | GWAS association (p=3.0e-14) | Large GWAS |
| rs113421210 | RPS6KA4 | GWAS association (p=3.0e-14) | Large GWAS |
| rs1816537 | — | GWAS association (p=4.0e-14) | Large GWAS |
| rs34185469 | ZNF184 | GWAS association (p=4.0e-14) | Large GWAS |
| rs2685484 | — | GWAS association (p=4.0e-14) | Large GWAS |
| rs2548458 | FUT2 | GWAS association (p=6.0e-14) | Large GWAS |
| rs12447915 | PPP4C | GWAS association (p=6.0e-14) | Large GWAS |
| rs1624440 | — | GWAS association (p=8.0e-14) | Large GWAS |
| rs35400317 | — | GWAS association (p=2.0e-13) | Large GWAS |
| rs7775835 | — | GWAS association (p=2.0e-13) | Large GWAS |
| rs9537109 | — | GWAS association (p=3.0e-13) | Large GWAS |
| rs4771935 | HS6ST3 | GWAS association (p=3.0e-13) | Large GWAS |
| rs72618696 | FANCL | GWAS association (p=3.0e-13) | Large GWAS |
| rs112987098 | — | GWAS association (p=3.0e-13) | Large GWAS |
| rs12785533 | TMX2 | GWAS association (p=3.0e-13) | Large GWAS |
| rs143311886 | — | GWAS association (p=4.0e-13) | Large GWAS |
| rs35092596 | HS6ST3 | GWAS association (p=4.0e-13) | Large GWAS |
| rs61905747 | ZW10 | GWAS association (p=5.0e-13) | Large GWAS |
Showing the top 100 of 766 variants by evidence strength.
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.