VRK2
VRK serine/threonine kinase 2
Summary
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]
Known Variants57 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs908731 | 2:58,135,010 | C/G | regulatory region variant | — |
| rs75575209 | 2:58,138,192 | A/G | — | — |
| rs2678901 | 2:58,138,651 | A/G | intron variant | — |
| rs1040225 | 2:58,139,593 | A/T | — | — |
| rs112176860 | 2:58,143,308 | G/A | intron variant | — |
| rs2717005 | 2:58,145,060 | A/G | intron variant | — |
| rs2678871 | 2:58,153,602 | G/A | intron variant | — |
| rs2139054 | 2:58,156,583 | A/G | — | — |
| rs2717033 | 2:58,166,769 | T/A | — | — |
| rs2678892 | 2:58,167,140 | G/A | intron variant | — |
| rs2678897 | 2:58,169,418 | G/A | intron variant | — |
| rs1518394 | 2:58,171,287 | A/C | — | — |
| rs2678898 | 2:58,171,964 | T/C | intron variant | — |
| rs77902252 | 2:58,172,395 | T/C | intron variant | — |
| rs17049270 | 2:58,192,905 | C/T | intron variant | — |
| rs966721 | 2:58,197,305 | T/A | intron variant | — |
| rs1518395 | 2:58,208,074 | A/G | intron variant | — |
| rs2312147 | 2:58,222,928 | T/A | — | — |
| rs60152647 | 2:58,242,037 | C/T | intron variant | — |
| rs2528351619 | 2:58,275,982 | A/G | — | uncertain significance |
| rs10205421 | 2:58,297,664 | G/C | — | — |
| rs371516428 | 2:58,311,247 | A/G | — | uncertain significance |
| rs1322434643 | 2:58,312,016 | G/A | — | uncertain significance |
| rs1274707992 | 2:58,315,489 | G/C | — | uncertain significance |
| rs368977421 | 2:58,315,498 | A/G | — | uncertain significance |
| rs754614058 | 2:58,315,550 | A/G | — | uncertain significance |
| rs768716776 | 2:58,315,577 | G/A | — | uncertain significance |
| rs76339147 | 2:58,333,771 | T/G | intron variant | — |
| rs13018289 | 2:58,344,792 | C/T | intron variant | — |
| rs111258777 | 2:58,346,019 | T/C | regulatory region variant | — |
| rs1677775232 | 2:58,350,252 | A/G | — | uncertain significance |
| rs147166402 | 2:58,350,279 | A/G | — | uncertain significance |
| rs750647897 | 2:58,350,327 | G/A | — | uncertain significance |
| rs144394613 | 2:58,350,333 | T/C | — | uncertain significance |
| rs1284767640 | 2:58,350,341 | A/G | — | uncertain significance |
| rs912137366 | 2:58,358,955 | G/A | — | uncertain significance |
| rs777534671 | 2:58,358,962 | C/G | — | uncertain significance |
| rs779052033 | 2:58,358,990 | C/T | — | uncertain significance |
| rs1034927922 | 2:58,358,991 | G/A | — | uncertain significance |
| rs12999901 | 2:58,361,134 | G/T | — | — |
| rs1158119781 | 2:58,366,801 | G/A | — | uncertain significance |
| rs978318198 | 2:58,366,861 | A/G | — | uncertain significance |
| rs140015622 | 2:58,366,890 | C/T | — | uncertain significance |
| rs768835989 | 2:58,366,927 | A/G | — | uncertain significance |
| rs185638327 | 2:58,373,452 | T/C | — | uncertain significance |
| rs146351868 | 2:58,373,500 | G/A | — | uncertain significance |
| rs766309498 | 2:58,373,516 | A/T | — | uncertain significance |
| rs765314013 | 2:58,373,532 | A/G | — | uncertain significance |
| rs377313037 | 2:58,373,542 | C/A | — | uncertain significance |
| rs563009246 | 2:58,377,864 | A/T | — | — |
| rs848294 | 2:58,381,785 | T/C | downstream gene variant | — |
| rs7596038 | 2:58,383,820 | C/T | downstream gene variant | — |
| rs903823275 | 2:58,386,515 | A/T | — | uncertain significance |
| rs778693777 | 2:58,386,554 | A/C | — | uncertain significance |
| rs2466516212 | 2:58,386,580 | A/G | — | uncertain significance |
| rs1684716072 | 2:58,386,593 | A/C | — | uncertain significance |
| rs2104762514 | 2:58,386,816 | A/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.