rs1518395

This is a intron variant variant in the VRK2 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

schizophrenia

Li Z et al. “Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia.” Nature Genetics 49(11):1576-1583 (2017)
Allele A
OR 1.16
p 4.0e-13
N 108,341
Large GWAS
multi-ancestry
Ikeda M et al. “Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.” Schizophrenia Bulletin 45(4):824-834 (2019)
Allele A
OR 1.14
p 1.0e-12
N 122,624
Large GWAS
multi-ancestry

major depressive disorder

Hyde CL et al. “Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.” Nature Genetics 48(9):1031-6 (2016)
Allele G
OR 0.03
p 4.0e-12
N 326,113
Large GWAS
European

wellbeing measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)
Allele G
OR 0.01
p 7.0e-9
N 80,852
Large GWAS
European
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Research that mentions this SNP (1)

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Evaluation of the relationship between VRK2, rs4380187 polymorphisms, and genetic susceptibility to schizophrenia in the Chinese Han population
AssociationN=986Xianglai Liu et al.(2021)· The Journal of Gene Medicine

A case-control study in 493 Chinese Han schizophrenia patients and 493 controls found that the C allele of rs4380187 (near ZNF804A) was significantly associated with decreased schizophrenia risk (OR=0.79, 95% CI: 0.66-0.94, p=0.008). The AA genotype showed significantly lower frequency in cases (OR=0.62, p=0.009), and associations were stronger in males (OR=0.64-0.68, p=0.002-0.003) and individuals aged ≥36 years.

Traits studied:schizophrenia
PubMedDOIMetascience Observatory

About VRK2

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]

View all VRK2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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