ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
Summary
This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation to acetaldehyde, thus playing a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. An association between ADH1C polymorphism and alcohol dependence has not been established. [provided by RefSeq, Sep 2019]
Known Variants39 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs774484394 | 4:100,257,924 | G/A | — | likely benign |
| rs1612735 | 4:100,258,007 | T/C | intron variant | — |
| rs1614972 | 4:100,258,155 | C/G | — | — |
| rs3846449 | 4:100,259,126 | T/C | intron variant | — |
| rs1693456 | 4:100,259,351 | G/T | — | — |
| rs62307295 | 4:100,260,545 | C/A | intron variant | — |
| rs561222871 | 4:100,260,679 | C/T | — | — |
| rs1339340687 | 4:100,260,771 | T/C | — | uncertain significance |
| rs35719513 | 4:100,260,783 | G/T | — | benign |
| rs698 | 4:100,260,789 | A/G | missense variant | protective |
| rs2298755 | 4:100,261,038 | C/A | — | — |
| rs769121542 | 4:100,261,758 | C/T | — | uncertain significance |
| rs751435373 | 4:100,261,813 | C/G | — | uncertain significance |
| rs200253359 | 4:100,261,822 | T/A | — | uncertain significance |
| rs1404410224 | 4:100,261,857 | A/C | — | uncertain significance |
| rs1789903 | 4:100,262,041 | C/A | — | — |
| rs141973904 | 4:100,262,242 | C/T | intron variant | — |
| rs6413446 | 4:100,263,945 | A/T | — | likely benign |
| rs553651224 | 4:100,263,946 | T/A | — | likely benign |
| rs1693482 | 4:100,263,965 | C/T | missense variant | protective |
| rs6413444 | 4:100,264,102 | G/A | — | benign |
| rs748191499 | 4:100,264,157 | A/G | — | likely benign |
| rs283411 | 4:100,265,957 | C/T | — | — |
| rs1001108935 | 4:100,266,030 | T/C | — | uncertain significance |
| rs55717907 | 4:100,266,064 | G/A | — | likely benign |
| rs541924884 | 4:100,266,095 | G/A | — | uncertain significance |
| rs2530191806 | 4:100,266,150 | T/A | — | uncertain significance |
| rs79372027 | 4:100,266,157 | G/A | — | likely benign |
| rs35725608 | 4:100,266,163 | G/A | — | likely benign |
| rs1192195322 | 4:100,266,215 | A/G | — | uncertain significance |
| rs778298993 | 4:100,266,227 | G/C | — | uncertain significance |
| rs283413 | 4:100,268,190 | A/C | stop lost | risk factor |
| rs2530196559 | 4:100,268,205 | T/C | — | uncertain significance |
| rs770118058 | 4:100,268,231 | A/G | — | likely benign |
| rs2530196778 | 4:100,268,267 | T/A | — | uncertain significance |
| rs35385902 | 4:100,268,279 | C/T | — | benign |
| rs2530198293 | 4:100,268,972 | T/G | — | uncertain significance |
| rs13147189 | 4:100,270,256 | T/A | — | — |
| rs1789924 | 4:100,274,286 | C/T | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.